… in this article are part of a treatment efficacy study that compared the sulfadoxine–pyrimethamine
(SP) … Unfortunately, our isolates did not include a genotype mutant at both 436 and 437 …

… Plasmodium falciparum dihydropteroate synthase (Pfdhps) and … Clinical trials to investigate
the efficacy of IPT-SP are much … Pyrimethamine binds far more strongly to the parasite DHFR …

… -108, which is associated with cycloguanil resistance [28–30]. … of SP treatment efficacy in
Gabon. These findings suggest … Treatment during infancy with sulfadoxine-pyrimethamine (…

… be incorporated with ongoing in vivo efficacy monitoring in areas … falciparum isolates
from Thies, as the increase in the number … Dhfr and dhps genotype and sulfadoxine–pyrimethamine …

… and sulfadoxine/pyrimethamine activity against parasite … To evaluate SP efficacy seven
years after Malawi replaced … between pyrimethamine and cycloguanil activity in vitro and …

… genotype and chemosensitivity to pyrimethamine. For the … associated with sulfadoxine-pyrimethamine
(SP) treatment failure … vitro susceptibility of Gabonese wild isolates of Plasmodium …

… with in vitro activity of pyrimethamine and cycloguanil, but not with sulfadoxine-pyrimethamine
treatment efficacy,” … falciparum: genotyping of dihydrofolate reductase and dihydropteroate …

… mutants that were associated with pyrimethamine resistance … three localities suggests the
efficiency of SP as IPTp. Citation62 This … treatment with sulfadoxine/pyrimethamine in Gabon. J …

… (IPTp-SP) efficacy is highly detrimental. The second … resistance to pyrimethamine and
sulfadoxine in vitro and in vivo, … neighbouring Cameroon was 6.25% in Gabon in 2007, 27 0.8% in …

… with resistance to pyrimethamine and pfdhps 436A/F/H and … /S, associated with resistance
to cycloguanil [18] and mutation … with genotypes known to compromise SP efficacy in Gabi are…